Neftaly 100 Proposals NIH R01 (Tobacco, Alcohol, Cannabis Policy & Health Equity) – Clinical Trial Optional

1‑10 | Policy Impact on Health Disparities

1. Differential Effects of Menthol Ban on Smoking Cessation Across Racial/Ethnic Groups – Compare quit rates among Black, Hispanic, and White smokers using a national longitudinal dataset.
2. State Cannabis Legalization & Adolescent Use Trends in Low‑Income Communities – Examine changes in past‑30‑day use via YRBS data stratified by socioeconomic status.
3. Alcohol Retail Density Policies & Heavy Drinking Outcomes in Rural Minority Populations – Geospatial analysis linking zoning laws to BRFSS outcomes.
4. Impact of Tobacco‑21 Laws on Young Adult Smoking Initiation Among LGBTQ+ Youth – Difference‑in‑differences analysis of PRISM and Add Health cohorts.
5. Equity Implications of Flavored E‑Cigarette Restrictions on Dual‑Use Patterns – Assess transition to combustible tobacco among African American and Asian smokers.
6. Cannabis Tax Revenue Allocation & Community Health Outcomes in Medically Underserved Areas – Evaluate investment in parks, mental‑health services, and ED visits.
7. Alcohol Pricing Policies & Binge Drinking Among American Indian/Alaska Native Adults – Use tribal census and CDC ALR data.
8. Smoke‑Free Housing Policies & Secondhand Smoke Exposure Disparities in Low‑Income Multi‑Unit Dwellings – Survey of HUD‑assisted residents across 10 states.
9. Differential Enforcement of Tobacco Retailer Licensing in Predominantly Black Neighborhoods – Spatial analysis of compliance checks and sales violations.
10. Impact of Recreational Cannabis Dispensary Openings on Alcohol Use Among Hispanic Adults – Interrupted time‑series using NSDUH data.
    11‑20 | Economic & Social Determinants
11. Tax Incidence of Cigarette Tax Increases on Low‑Income Smokers – Model out‑of‑pocket costs vs. cessation benefits by income quartile.
12. Cannabis Legalization & Labor Market Outcomes for Marginalized Workers – Examine employment and wages in states with adult‑use laws.
13. Alcohol Minimum Unit Pricing & Household Expenditure Patterns in Food‑Insecure Households – Cross‑sectional analysis of Consumer Expenditure Survey.
14. Impact of Tobacco Retailer Density Restrictions on Neighborhood Socioeconomic Mobility – Longitudinal study linking zoning changes to mobility scores.
15. Cannabis Advertising Bans & Brand Preference Among Youth from Low‑Education Households – Experimental survey with choice‑based conjoint.
16. Alcohol Outlet Density Near Universities & Binge Drinking Among First‑Generation Students – GIS and campus health survey integration.
17. Differential Impact of Tobacco 21 on Military Personnel vs. Civilians – Use DoD and ACS data to compare smoking initiation rates.
18. Equity Effects of Cannabis Home‑Cultivation Policies on Rural Cannabis Use – Survey of rural adults in states permitting home grow.
19. Impact of Menthol Product Bans on Cross‑Border Purchasing Among Border Communities – Spatial econometrics using retail scanner data.
20. Alcohol Warning Label Policies & Drinking Knowledge Among Limited English Proficiency Populations – Multilingual randomized vignette study.
    21‑30 | Implementation Science & Scale‑Up
21. Scaling Evidence‑Based Tobacco Cessation Interventions in Federally Qualified Health Centers (FQHCs) – Hybrid Type II implementation‑effectiveness trial.
22. Integrating Cannabis Use Screening into Substance Use Disorder Treatment Programs – Cluster‑randomized trial in community health clinics.
23. Policy‑Level Barriers to Alcohol Screening & Brief Intervention (SBI) in Rural Primary Care – Mixed‑methods study using RE‑AIM framework.
24. Dissemination of Alcohol Server Training Programs in Underserved Urban Bars – Pragmatic stepped‑wedge design.
25. Implementation of Culturally Tailored Cannabis Education Materials for Hispanic/Latino Parents – Community‑partnered participatory research.
26. Telehealth Tobacco Cessation Services for Rural American Indian Communities – Cost‑effectiveness analysis alongside a randomized trial.
27. Scale‑Up of Smoke‑Free Multi‑Unit Housing Policies in Affordable Housing Networks – Quasi‑experimental design with policy champions.
28. Policy Monitoring System for Cannabis Retail Compliance Across States – Develop a GIS‑based dashboard for state regulators.
29. Adoption of Alcohol Advertising Restrictions on Social Media Platforms – Content analysis and stakeholder interviews.
30. Integration of Tobacco, Alcohol, Cannabis Use Assessments into Electronic Health Records (EHRs) – Workflow analysis and usability testing.
    31‑40 | Biomarkers & Molecular Mechanisms
31. Epigenetic Age Acceleration in Heavy Alcohol Users Exposed to Secondhand Cannabis Smoke – Longitudinal DNA methylation study.
32. Urinary Metabolites of Tobacco Carcinogens in Menthol vs. Non‑Menthol Smokers – LC‑MS/MS profiling across racial groups.
33. Neuroinflammatory PET Imaging of Microglial Activation in Heavy Cannabis Users – ¹⁸F‑DPA‑714 PET in diverse cohort.
34. Telomere Length Attrition in Peripheral Blood of Dual Alcohol & Tobacco Users – qPCR study with matched controls.
35. Proteomic Signature of Alcohol‑Related Liver Disease in Smokers vs. Non‑Smokers – Plasma DIA‑MS analysis.
36. Cannabinoid Receptor (CB1/CB2) Expression in Lung Tissue of Menthol Cigarette Smokers – Immunohistochemistry and spatial transcriptomics.
37. Exosomal miRNA Cargo in Plasma of Adolescents Initiating Vaping vs. Combustible Tobacco – Small‑RNA sequencing.
38. Interaction Between Alcohol Use & CYP2A6 Polymorphisms on Nicotine Metabolism – Pharmacokinetic study in African American participants.
39. Serum Cytokine Profile Associated with Cannabis Use Disorder Severity Across Gender – Multiplex immunoassay.
40. DNA Damage Markers (8‑OHdG) in Oral Cells of Smokers Exposed to Flavored E‑Cigarettes – Cross‑sectional biomarker study.
    41‑50 | Social & Environmental Contexts
41. Neighborhood Disadvantage & Tobacco Retail Exposure: A Multi‑Level Study of Latino Immigrants – Combine census tract data with GIS mapping.
42. Impact of Cannabis Legalization on Workplace Safety in Low‑Wage Industries – Analysis of OSHA incident reports and state policy data.
43. Alcohol Outlet Density Near Homeless Shelters & Substance Use Disorders – Spatial regression with HUD dataset.
44. Exposure to Tobacco‑Related Social Media Content & Susceptibility to Vaping Among Black Youth – Longitudinal digital trace analysis.
45. Intersectionality of Sexual Minority Status & Racial Discrimination in Alcohol Use Outcomes – Intersectional multilevel modeling using national surveys.
46. Cannabis Use Norms Among Immigrant Communities: A Mixed‑Methods Study of Acculturation – Surveys + focus groups in Somali and Mexican populations.
47. Impact of Smoke‑Free Parks Policies on Physical Activity Levels in Low‑Income Families – Accelerometer data linked to policy roll‑out.
48. Effect of Tobacco Tax Earmarking on Funding for Community Health Programs in Minority Neighborhoods – Policy analysis and budget tracking.
49. Alcohol Advertising Exposure via Streaming Services & Binge Drinking Among Young Adults of Color – Content exposure modeling.
50. Cannabis Retailer Proximity to Schools & Perceived Availability Among Rural Adolescents – GIS and school‑based survey.
    51‑60 | Policy Evaluation & Comparative Effectiveness
51. Comparative Impact of State‑Level Cannabis Tax Structures on Unregulated Market Persistence – Difference‑in‑differences across states.
52. Effectiveness of Mandatory Health Warnings on Alcohol Containers in Reducing Heavy Drinking – Cross‑state comparison with BRFSS data.
53. Evaluation of Tobacco Retail Licensing Fees on Store Density in Disadvantaged Areas – Interrupted time‑series analysis.
54. Impact of Flavored Tobacco Ban on Smuggling Activity in Border Regions – Analysis of seizure data and econometric modeling.
55. Cannabis Purity Testing Laws & Presence of Contaminants in Legal Markets – Laboratory testing across multiple states.
56. Alcohol Minimum Age Enforcement & Traffic Fatalities Among Hispanic Young Adults – Synthetic control study.
57. Policy Spillover Effects of E‑Cigarette Flavor Bans on Cigarette Smoking Prevalence – Multi‑state panel data analysis.
58. Impact of Smoke‑Free Multi‑Unit Housing on Cigarette Consumption Among Low‑Income Adults – Longitudinal cohort study.
59. Effect of Cannabis DUI Laws on Motor Vehicle Crash Mortality – Quasi‑experimental design using NCHS data.
60. Comparative Cost‑Effectiveness of Tax vs. Advertising Restrictions for Reducing Alcohol-Related Mortality – Microsimulation modeling.
    61‑70 | Innovative Data & Methodologies
61. Machine Learning Prediction of Cannabis Use Disorder From EHR + Social Media Data – Develop and validate a risk algorithm.
62. Natural Language Processing of Clinical Notes to Identify Tobacco, Alcohol, Cannabis Co‑Use Patterns – Cross‑institutional NLP pipeline.
63. **Spatial Temporal Bayesian Model of